慢性脑卒中运动皮质区神经元损伤与下肢功能缺损基于体素的病灶-症状图研究.docVIP

Neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxel-based lesion symptom mapping study Alexandria M. Reynolds?1, Denise M. Peters?2, Jennifer M. C. Vendemia?3, Lenwood P. Smith?4, Raymond C. Sweet?4, Gordon C. Baylis?5, Debra Krotish?6, Stacy L. Fritz?2 1 Department of Psychology, Barnwell College, University of South Carolina, Columbia, SC, USA2 Department of Exercise Science, University of South Carolina, Columbia, SC, USA?3 Department of Psychology, University of South Carolina, Columbia, SC, USA?4 Neurosurgery Center, University of South Carolina School of Medicine, Columbia, SC, USA5 Western Kentucky University, Bowling Green, KY, USA6 University of South Carolina School of Medicine, Columbia, SC, USA 摘要? 应用基于体素的病灶-症状图评估运动缺损情况的研究有许多，但应用该技术研究大脑皮质神经损伤与下肢功能缺损对应的关系的报道尚未见。此次实验应用基于体素的病灶-症状图分析16例左侧大脑半球脑出血的慢性脑卒中患者大脑皮质神经元损伤与下肢运动功能的关系。结果显示，纳入患者放射冠、尾状核、壳核神经元损伤可预测步行速度发展趋势。脑卒中后运动皮质系统损伤预期可能产生的运动缺损与行为学变化一致。说明基于体素的病灶-症状图可以通过大脑运动皮质神经元损伤区预测脑卒中患者运动功能恢复情况。 关键词：?神经再生；?MRI；?脑卒中；?大脑皮质；?运动皮质系统；?基于体素的病灶-症状图;运动功能；?预后； Fund:?USC McCausland大脑影像中心基金 Acceptance date:?2014-03-10 Cite this article: Alexandria M. Reynolds, Denise M. Peters, Jennifer M. C. Vendemia, Lenwood P. Smith, Raymond C. Sweet, Gordon C. Baylis,Debra Krotish, Stacy L. Fritz . Neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxel-based lesion symptom mapping study[J].Neural Regeneration Research, 2014, 9 7 : 766-772.