Fyn基因多态性(rs706895%2crs3730353%2crs6916861)和健康中国汉族成年人应对方式的相关性研究.pdfVIP

应对评分(rs706895：贮--2．30，P=O．32；rS3730353：z2=5．21，P--O．07；rS6916861： )c2=3．27，P=O．20)均无明显相关性，差异无统计学意义。然而，在性别相关分析中， 女性消极应对评分与rs3730353及rs6916861的多态性表现出了明显的相关性 (rs3730353：z2=8．27，P=O．01 8；rs691 6861：)(2=7．84，P=O．020)，差异具有统计学意义。 结论 研究结果表明Fyn基因多态性与健康中国汉族女性人群的消极应对方式具有 明显的相关性。 关键词 Fyn，基因多态性，应对方式，中国汉族人群 5 ·英文论著摘要· Genetic variation of Fyn contributes to the molecular mechanisms of coping styles in healthy Chinese-Han subjects Objective Coping styles ale defined嬲stable psychological and behavioral strategies to overcome or tolerate external and internal challenges or stressors．Coping styrle is a stable trait drawn upon in a wide variety of stressful situations．Multiple schemes incorporating distinct coping strategies have been propose and three broad coping styles ale distinguishable．The first two，‘problem-focused coping’and“seeking help’’ or‘turning to others’，are active or mature coping styrles that are considered signs of adaptive functioning．The third is“avoidance’，also termed paSsive or emotion-focused coping，and is considered a less effective coping style．Genetic factors Can influence specific human coping styles．Polymorphisms in the Src family tyrosine kinase FYN gene have been aSsociated winl several personality traits．but no studies have examined the possible relationship between FYN alleles and coping styles．To this end，we examined the aSsociation between three single nucleotide polymo叩hisms of FYN (rs3730353，rs6916861，and rs706895)and coping styles硒meaSured by the Coping Styles Questionnaire in healthy Chinese-Hart subjects． Methods We genotyped three polymo印hisms(rs706895，rs3730353，and rs6916861)ofthe FYN in 488 healthy Chinese·Hart subjects without previous histories of neurological， psychiatric，or chronic physical illnesses．Their mean 4-SD age WaS 30．95 4-7．98 years (删19e：19_58 years)．All subjects were informed ofall experimental protocols and gave their informed consent．The Chinese version of the Coping Styles Questionnaire，which has been shown to be highly reli