加味当归补血汤对肿瘤转移过程中血液流变学的影响(精选).docVIP

加味当归补血汤对肿瘤转移过程中血液流变学的影响 龚继勇1 张奉梅2 王兴武1 齐宝凤1 （1 山东省肿瘤医院 山东济南 250117 2 滨州医学院 山东烟台 264003） 摘要：目的：探讨加味当归补血汤是否具有改变肿瘤转移过程中血液流变学状态从而抑制肿瘤转移的作用。方法：小鼠U14宫颈癌肺转移造模，于10d、19d、25d测全血粘度、血小板聚集率、红细胞压积、血小板计数及计算红细胞聚集指数率。结果：10d、19d，中药组与模型组相比全血粘度三个切变率均有所降低，尤其低切变率较模型组显著下降，P 0.05。血小板最大聚集率较模型组显著下降，P 0.05。25d，中药组低切变率较模型组显著升高，P 0.05；其余指标各组比较差异不明显，P 0.05，血小板最大聚集率较模型组显著下降，P 0.01。结论：加味当归补血汤通过降低肿瘤小鼠升高的血液黏度、降低血小板聚集率升高来影响血液流变学从而具有一定的抑制肿瘤转移的作用。 关键字：加味当归补血汤，肿瘤转移，血液流变学 Modified Dangguibuxue Tang on tumor metastasis in the course of the impact of hemorheology Gong Jiyong1 Zhang Fengmei 2 Wang XingWu1 Qi Baofeng 1 1 Cancer Hospital in Shandong Province, Jinan, Shandong 250117 2 Binzhou Medical College Yantai, Shandong 264003 Abstract: Objective: To investigate whether the Modified Dangguibuxue soup with changes in the process of tumor metastasis hemorheology state to inhibit tumor metastasis role. Method: U14 cervical cancer in mice lung metastases model, in the 10 d, 19d, 25d measuring blood viscosity, platelet aggregation, hematocrit, platelet count and red blood cell aggregation index was calculated. Results: 10 d, 19d, the Board compared with the model of whole blood viscosity three shear rate has decreased, especially low-shear rate than the model group dropped significantly, P 0.05. Platelet aggregation model group than the rate dropped significantly, P 0.05. 25 d, the Board of low shear rate than the model group were significantly higher, P 0.05; other indicators of the difference between the groups was not obvious, P 0.05, platelet aggregation A significant decline in the model group, P 0.01. Conclusion: Modified Dangguibuxue soup tumors in mice by reducing elevated blood viscosity, reducing platelet aggregation rate increased to influence hemorheology thus has a role in inhibiting tumor metastasis. Keyword: Modified Dangguibuxue soup, tumor metastasis, hemorheology 现代研究已经证实恶性肿瘤患者血液呈高凝状态，血流变慢，使脱落的肿瘤细胞不易被冲刷而附壁；同时产生的血栓也易产生涡流，为分散的癌细胞提供了整合、粘附机会，脱落的癌细胞易从轴流处移向管壁边流，可能陷入内皮细胞不规则处或附于血栓表面被包裹，从而