北京地区帕金森病药物治疗状况的调查和我国帕金森病治疗指南对药物治疗影响的研究.pdf

目 录 中文摘要··········-···········································6 英文摘要···········································“·········8 前 言······················································10刖 舌。。。。。。。‘‘。。。‘。。‘。。。。。。。。。。。‘。。。。。。。‘。‘。。。。’。‘‘。。。。。。。。lu 资料与方法··················································一13 结 果······””·“·····“”·”””·”””—·“·“··”·““··16 讨 论···········································”·········29 结 论··········································”··········36 参考文献··················^．···································37 综 述······················································39 参考文献·····································一······”“””·47 致{射·······························”·····················49 4 CATALoGUE ChineseAbstract··············································-··-····6 EngliShAbs仃act······················································8 In臼．oduction·························································10 Patients锄d metllods·······························一·················13 Results···················”········································16 Discussion·········-··········································-·····29 CollclusiollS·························································36 R．eferences··························································37 Review。············．．·．．···-．．．·．．．．·······．．·．．．．．．··．．··········．39 R-ef．ercInces‘·························································47 Acl(Ilowledg锄ent··································‘····。。‘··。·。··。。-49 5 北京地区帕金森病药物治疗状况的调查及我国帕金森病治 疗指南对药物治疗影响的研究 专 业：神经病学 硕士研究生：南海天 导 师：陈海波教授 中文摘要 目的：研究2006年我国帕金森病治疗指南的推出对帕金森病人的初始用药的 影响情况，并对目前北京地区帕金森病人用药情况进行流行病学调查。 方法：筛选符合入组标准的136名原发性帕金森病患者进行调查。调查的内 容主要包括患者首次处方医院及级别、首次服药时间、首次服药名称、是否伴有 其他疾病、医保类型、月平均药物费用以及患者目前及既往药物使用情况。调查 指南对神经内科医生处方的影响时，将首次用药为左旋多巴制剂和多巴胺受体激 动剂进行对比，以2007年1月和2010年1月作为两个时间点，将年龄分界线划 定为65岁，分析在2006年以前(包括2006年)、2007—2009年、2010年之后 (包括20lO年)三个时间段内，两个不同年龄组的患者左旋多巴制剂和多巴胺 受体激动剂的使用情况。将首次处方医院按级别分为三甲和非三甲两大类，分析 两类医院左旋多巴制剂与多巴胺受体激动剂的处方情况。分析不同医保类型对患 者首次用药是左旋多巴制剂还是多巴胺受体激动剂的