Bridging Therapy No differences in symptomatic intracranial hemorrhage was found No differences in mortality was found Mazighi M, et al. Stroke, 2012;43:1302-08 Bridging Therapy Although these positive efficacy and safety findings favor the bridging therapy approach, there is no data from RCTs Randomized trial--Interventional Management of Stroke III (IMS-III) Target N=900 Iv rtPA alone (0.9 mg/kg) vs combined IV/IA (0.6 mg/kg over 30 min followed by immediate angiography. If clot is demonstrated, the neuro-interventionalist will then choose from currently
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