同种异基因小鼠骨髓移植GVHD模型的建立与OGT2115对小鼠气管移植排斥反应的影响.pdfVIP

目 录 中文摘要??????????????????????????????????1 Abstract??????????????????????????????????????．．3 1前言???????????????????????????????????????。6 1．1研究背景???????????????????????????．6 1．2研究目的???????????????????????????．7 1．3研究内容???????．．j???????????????????一8 2同种异基因小鼠骨髓移植移植物抗宿主动物模型的建立??????????。9 2．1材料与方法??????????????????????????．9 2．2结果??????????????????????????????????????16 2．3讨论??????????????????????????????????????20 3同种气管移植排斥反应动物模型的建立??????????????????．23 3．1材料与方法??????????????????????????23 3．2结果????????????????????????????．．24 3．3讨论??????????????????????????????????????25 4乙酰肝素酶抑制剂OGT2115对同种气管移植排斥反应的影响??????。27 4．1材料与方法??????????????????????????27 4．2结果????????????????????????????．．28 4．3讨论??????????????????????????????????????29 5小结???????????????????????????????????????31 参考文献??????????????????????????????．．32 文献综述1???????????????????????????????。36 文献综述2???????????????????????????????。45 致谢??????????????????????????????．52 附录一缩写词中英文对照?????????????????????53 附录二在读硕士期间的科研情况??????????????????。55 Contents Abstract in Chinese??．．???????．????．．???．??????????．????．1 Abstract in EngUsh?????????????????????????????????3 1 Introduction．．．．．．．．?．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．6 1．1 Background???????????????????????????????????．6 1．2 Objective??．??????????．??????????????．??????．???．7 1．3 Comems???．?．???????．?????????????????????????8 2 Establishment of animal model for graft-verusu-host diseases?????????9 2．1 Materials and Methods??????????????????????????????9 2．2 Results?????????????????????????????????????．16 2．3 Discussion???????????????????????????????????．20 3 Establishment of animal model for allogenic trachea transplant rejection??．23 ：；．1 Materials and Methods?????????????????????????????．23 ：；．2 Resuks?????????????????????????????????????．24 3．3 Discussion???????????????????????????????????．25 4 E仃ect of heparin inhibitor oGT2115 on allogenic trachea transplant rejection27 4。1 Materials and Methods???