n受体激动药.pptVIP

Co-innervation and Dominant Theory Sympathetic actions : Heart and blood vessel Parasympathetic actions : heart rate, exocrine glands, smooth muscle, eyes Section 4 The basic mechanisms of actions and classification of the ENS drugs The basic mechanisms of actions of ENS drugs 1.Direct action of receptors agonist antagonist (blocker) 2.lnfluence of neurotransmitters Biosynthesis release transshipment and storage conversion The classification of the ENS drugs 拟似药 拮抗药 副 胆碱受体激动药 胆碱受体阻断药 交 M受体激动药（毛果芸香碱） N受体激动药（烟碱） M受体阻断药（阿托品） N受体阻断药（琥珀胆碱） 感 抗胆碱酯酶药（新斯的明） 胆碱酯酶复活药（碘解磷定） 肾上腺素受体激动药 肾上腺素受体阻断药 交 α受体激动药 α1、α2受体激动药（NE） α1受体激动药（去氧Adr) α2受体激动药（可乐定） α受体阻断药 α1、α2受体阻断药（酚妥拉明） α1受体阻断药（哌唑嗪） α2受体激动药（育亨宾） 感 β受体激动药 β受体阻断药 β1、β2受体激动药（Isop） β1受体激动药（多巴酚丁胺） β2受体激动药（沙丁胺醇） β1、β2受体阻断药（普萘洛尔） β1受体阻断药（阿替洛尔） β2受体阻断药（布他沙明） α、β受体激动药（Adr) α、β受体阻断药(拉贝洛尔） Chapter 5 Introduction to Pharmacology of Efferent Nervous System Zhang Bin Institute of Pharmacology School of Medicine Shandong University Section 1 Overview and Classification of ENS Organization of Nervous system Efferent neurons of the autonomic nervous system ganglion Classification of ENS according to the released neurotransmitters cholinergic nerve: acetylcholine (Ach) noradrenergic nerve: noradrenaline ( NA) Classification of ENS Parasympathetic nerve Central nervous system Ach skeletal muscle Ach NA Ach Ach sweat glands Ach … AD,NA Ach Ach adrenal medulla somatic motor nerve sympathetic nerve glands, smooth muscle, heart heart, vessel, smooth muscle The cholinergic fibers include: 1.the somatic nerve endings 2.all pre-ganglionic nerve endings 3.parasympathetic post-ganglionic nerve endings 4.the nerve endings to adrenal medulla 5.few sympathetic postganglionic ner