磷酸西格列汀对2型糖尿病患者血脂的影响.docVIP

磷酸西格列汀对2型糖尿病患者血脂的影响 　　[摘要] 目的 观察磷酸西格列汀对2型糖尿病患者血脂的影响。 方法 选取2013年7月～2014年11月我院收治的40例2型糖尿病患者，均给予磷酸西格列汀（100 mg，1次/d）治疗24周，观察治疗前后患者的空腹血糖、餐后2 h血糖、糖化血红蛋白、体重指数、血脂、血尿酸的变化。 结果 治疗12周后与治疗前相比，患者的空腹及餐后血糖、糖化血红蛋白均有所降低（P0.05）；治疗24周后与治疗前相比，患者的空腹及餐后血糖、糖化血红蛋白、总胆固醇、三酰甘油及低密度脂蛋白胆固醇均显著降低（P0.05）。 结论 磷酸西格列汀可有效控制2型糖尿病患者的血糖水平，同时改善血脂水平。 　　[关键词] 磷酸西格列汀；2型糖尿病；血糖；血脂 　　[中图分类号] R587.1 [文献标识码] A [文章编号] 1674-4721（2016）01（b）-0121-03 　　Impact of sitagliptin phosphate on blood lipid of patients with type 2 diabetes 　　LU Ying ZOU Shui-lan KONG Xia 　　General Medicine，Aviation General Hospital，Beijing 100012，China 　　[Abstract] Objective To observe the impact of sitagliptin phosphate on blood lipid of patients with type 2 diabetic. Methods 40 patients with type 2 diabetic admitted into our hospital from July 2013 to November 2014 were selected.All patients were treated with sitagliptin phosphate （100 mg，once a day） for 24 weeks.The changes of fasting blood glucose，2 hours postprandial hyperglycemia，glycosylated hemoglobin，body weight index，blood lipid and blood uric acid in patients were observed before and after treatment. Results Compared with treatment for 12 weeks and before treatment，the level of fasting blood glucose，postprandial hyperglycemia，glycosylated hemoglobin was decreased（P0.05）.Compared with treatment for 24 weeks and before treatment，the level of fasting blood glucose，postprandial hyperglycemia，glycosylated hemoglobin，total cholesterol，triglyceride and low density lipoprotein cholesterol was obvious decreased（P0.05）. Conclusion Sitagliptin phosphate can effective control blood glucose of patients with type 2 diabetic and improve blood lipid level. 　　[Key words] Sitagliptin phosphate；Type 2 diabetes；Blood glucose；Blood lipid 　　随着生活方式的改变和老龄化进程的加速，我国糖尿病的发病率正呈快速上升的趋势，通过对糖尿病治疗研究的不断深入，肠促胰素的作用越来越被人们所重视。肠促胰素是人体内一种肠源性激素，进食后该激素可促进胰岛素分泌，发挥葡萄糖浓度依赖性降糖作用。肠促胰素主要由胰高血糖素样多肽-1（GLP-1）和葡萄糖依赖性促胰岛素分泌多肽（GIP）组成，其中GLP-1在2型糖尿病的发生发展中起着更为重要的作用。循环中的GLP-1会被二肽基肽酶-4（DPP-4）降解代谢，DPP-4抑制剂通过抑制DPP-4而减少GLP-1在体内的失活，使内