胸腺瘤组织中c―myc和PTEN基因的表达.docVIP

胸腺瘤组织中c―myc和PTEN基因的表达 　　【摘要】 目的：探讨c-myc、PTEN基因在胸腺瘤中的表达及其与胸腺瘤临床病理特征的关系。方法：采用免疫组织化学SP法检测45例胸腺瘤（胸腺瘤组）和16例非肿瘤（对照组）胸腺组织中c-myc、PTEN基因的表达。结果：胸腺瘤组c-myc基因阳性表达率高于对照组，PTEN基因阳性表达率低于对照组，比较差异均有统计学意义（P0.01）；恶性组c-myc基因阳性表达率高于良性组，PTEN基因阳性表达率低于良性组，比较差异均有统计学意义（P0.05）；侵袭性组c-myc基因阳性表达率高于非侵袭性组，PTEN基因阳性表达率低于非侵袭性组，比较差异均有统计学意义（P0.01）；PTEN基因表达与c-myc表达呈负相关（P0.01）。结论：c-myc、PTEN共同参与胸腺瘤的发生、发展，与胸腺瘤的恶性程度及侵袭性呈正相关，二者存在协同作用。 　　【关键词】 胸腺瘤； c-myc基因； PTEN基因 　　【Abstract】 Objective：To evaluate the expression of c-myc and PTEN in thymomas and their correlation with clinical pathological characteristics of thymomas.Method：Immunohistochemical SP assay was used to detect the expression of c-myc and PTEN in thymus issues of 45 thymoma patients（the thymoma group）and 16 non-neoplastic patients（the control group）.Result：The positive expression rate of c-myc in the thymoma group was higher than that in the control group，the positive expression rate of PTEN in the thymoma group was lower than that in the control group，the differences were statistically significant（P0.01）.The positive expression rate of c-myc in the malignancy group was higher than that in the benign group，the positive expression rate of PTEN in the malignancy group was lower than that in the benign group，the differences were statistically significant（P0.05）.The positive expression rate of c-myc in the invasiveness group was higher than that in the non-invasive group，the positive expression rate of PTEN in the invasiveness group was lower than that in the non-invasive group，the differences were statistically significant（P0.01）.There was a negative correlation between the expression of PTEN gene and the expression of c-myc gene（P0.01）.Conclusion：C-myc and PTEN may play an important role in the occurrence and development of thymoma.The expression of c-myc and PTEN correlates with the malignance and the invasiveness of thymoma.They have a synergistic effect. 　　【Key words】 Thymoma； C-myc gene； PTEN gene 　　First-author’s address：The First Affilia