自拟健脾化湿汤佐治非酒精性脂肪肝78例疗效分析.docVIP

自拟健脾化湿汤佐治非酒精性脂肪肝78例疗效分析 　　摘要：目的 探讨自拟健脾化湿汤佐治非酒精性脂肪肝的临床疗效。方法 选取2014年11月―2015年9月本院收治的156例非酒精性脂肪肝患者作为研究对象，按照随机数字表法分为研究组和对照组，每组78例，2组一般资料比较差异无统计学差异。对照组使用多烯磷脂酰胆碱胶囊治疗，研究组在对照组基础上使用自拟健脾化湿汤治疗。比较2组患者治疗总有效率、治疗前后肝功能（丙氨酸氨基转移酶ALT、天冬氨酸转移酶AST、谷氨酰氨转肽酶GGT含量）变化情况的差异。结果 研究组治疗总有效率为91.0%，对照组为79.5%，研究组优于对照组高（P0.05）；治疗后，研究组ALT、AST、GGT等含量均优于对照组（P0.05）。结论 自拟健脾化湿汤佐治非酒精性脂肪肝疗效突出，对改善患者肝功能有积极作用，值得临床推广使用。 　　关键词：自拟健脾化湿汤；非酒精性脂肪肝；多烯磷脂酰胆碱；肝功能 　　中图分类号：R256.4 文献标志码：B 文章编号：1007-2349（2016）06-0043-03 　　【Abstract】Objective： To study the clinical effect of self-prescribed decoction for invigorating spleen to resolve dampness for adjunctive treatment of nonalcoholic fatty liver patients. Methods： 156 patients who received treatment in our hospital from November，2014 to September，2015 were selected and randomly divided into a test group and a control group，78 cases per group. The general information of the two groups had no significant difference. The control group was treated with polyene phosphatidylcholine capsule while the test group was added this self-prescribed decoction on the basic treatment of the control group. The differences of liver function（ALT，AST，GGT and GGT）of the two groups were compared before and after the treatment. Results： The total effective rate of the test group was 91.0% while that of the control group was 79.5%. The test group was better than the control group（P0.05）. After the treatment，ALT，AST and GGT of the test group were lower than those of the control group（P 0.05）. Conclusion： Self-prescribed decoction for invigorating spleen to resolve dampness has an obvious effect on the adjunctive treatment of nonalcoholic fatty liver patients，and positively improves liver function，worthy of clinical application. 　　【Key words】self-prescribed decoction for invigorating spleen to resolve dampness，non-alcoholic fatty liver，polyene phosphatidylcholine，liver function 　　随着现代人们生活习惯的改变，脂肪肝的发病率逐年升高。非酒精性脂肪肝是指非酒精因素引起的肝细胞内脂肪过度沉积。非酒精性脂肪肝可直接导致失代偿期肝硬化、肝细胞癌和移植肝复发[1]。研究表明，非酒精性脂肪肝的发病与胰岛素抵抗、遗传易感等因