IL―6水平检测与重症并发感染者的相关性分析.docVIP

IL―6水平检测与重症并发感染者的相关性分析 　　【摘要】 目的：研究IL-6水平检测与重症并发感染者的相关性。方法：选择2013年1月-2014年12月本院接诊的73例重症患者（APACHEⅡ评分12），按照是否并发感染分为重症并发感染组（41例）和重症非并发感染组（32例），并随机从本院健康体检的人群中选择30例正常者作为对照组，使用放射免疫分析法测定三组血清IL-6水平，比较并分析IL-6水平与APACHEⅡ评分的相关性。结果：重症非并发感染组患者的血清IL-6水平（131.25±51.82）pg/mL明显高于对照组（83.98±31.15）pg/mL，重症并发感染组的血清IL-6水平（154.08±53.06）pg/mL亦明显高于对照组，比较差异均有统计学意义（P0.05）。重症非并发感染组患者的血清IL-6水平与其APACHEⅡ评分呈正相关关系（r=0.793，P=0.0004）；重症并发感染组患者的血清IL-6水平与其APACHEⅡ评分亦呈正相关关系（r=0.864，P=0.0001）。重症非并发感染组和并发感染组血清IL-6阳性率均明显高于对照组，比较差异均有统计学意义（P0.05）。结论：重症患者无论是否并发感染，其血清IL-6水平均显著升高，且IL-6水平升高程度与患者损伤的严重程度呈正相关。 　　【关键词】 重症； 并发感染； IL-6 　　【Abstract】 Objective： To research the relevance of IL-6 levels and severely infected person with infection. Method： 73 severe illness patients （APACHEⅡ score12） from January 2013 to December 2014 in our hospital were selected and divided， according to whether concurrent infection complicated， into severe infection group （41 cases） and non-concurrent infection group （32 cases）， and 30 normal healthy cases were randomly selected from our hospital as control group. The serum IL-6 level was detected by using radioimmunoassay. To compare three groups IL-6 levels and a correlation of IL-6 levels and APACHEⅡscores. Result： The serum IL-6 level of the severe non-concurrent infection group （131.25±51.82）pg/mL was significantly higher than that of the control group （83.98±31.15）pg/mL， and the difference was statistically significant （P0.05）. Serum IL-6 level of the severe non-concurrent infection group and its APACHEⅡscore showed a positive correlation （r=0.793，P=0.0004）. Serum IL-6 level of infected patients with severe concurrent and its APACHEⅡ scores were positively correlated （r=0.864，P=0.0001）. Serum IL-6 positive rate of the severe non-concurrent infection group was significantly higher than that of the control group， severe concurrent infection serum IL-6 positive rate was significantly higher that of the control group， the difference was statistically significant （P 　　【Key words】