综合康复对大鼠受压坐骨神经微血管生成的影响.docVIP

综合康复对大鼠受压坐骨神经微血管生成的影响 【摘要】 目的：观察综合康复对大鼠受压坐骨神经微血管生成的影响。方法：参照经典Mackinnon大鼠坐骨神经卡压模型制作动物模型，40只大鼠完全随机分为A、B、C、D 4组，每组10只，2周后，A组（对照组）：仅去除卡压；B组（康复训练组）：去除卡压后行康复训练；C组（电针组）：去除卡压后行电针治疗；D组（康复训练+电针组）：去除卡压后行康复训练加电针治疗。术后第3周各组治疗结束。观察各组大鼠大体情况、坐骨神经功能指数（SFI）、卡压神经中段标本CD34、VEGF表达。结果：B、C、D组SFI恢复程度均大于A组（P 0.05）；D组SFI恢复程度明显大于B组与C组（P 0.05）。B、C、D组CD34、VEGF表达明显高于A组（P 0.05）；D组CD34、VEGF表达明显高于B组与C组（P 0.05）。结论：综合康复可以有效促进大鼠受压坐骨神经微血管生成，进而促进神经再生与功能恢复。 【关键词】 综合康复； 神经微血管生成； 神经再生； 坐骨神经 Effect of Comprehensive Rehabilitation on Neural Micro-angiogenesis in Rat with Sciatic Nerve Compression/ZHANG Shan-shan，DU Zhen-sheng，CHEN Feng，et al.//Medical Innovation of China，2015，12（18）：015-017 【Abstract】 Objective：To observe the the effect of comprehensive rehabilitation on neural micro-angiogenesis in rat with sciatic nerve compression.Method：According to the rat model of sciatic nerve compression designed by Mackinnon，forty male SD rats were chosen and randomly divided into 4 groups（n 10）：group A，group B，group C，and group D.After 2 weeks，compression were removed in all 4 groups，and no treatment was given in group A，rehabilitation training in group B，electroacupuncture in group C，electroacupuncture combined with rehabilitation training in group D.At 3 weeks after treatment，the sciatic nerve function index （SFI），and the expression of CD34，VEGF in the compression sciatic nerve of rats were measured.Result：The SFI recovery rate of groups B，C，and D were significantly higher than that of group A（P 0.05），and that of group D was significantly higher than that of groups B and C（P 0.05）.The expression of CD34 and VEGF in the compression sciatic nerve of groups B，C，and D were significantly higher than that of group A（P 0.05），and that of group D was significantly higher than that of groups B and C（P 0.05）.Conclusion：Comprehensive rehabilitation can improve neural micro-angiogenesis in rat with sciatic nerve compression，thereby it can promote the nerve regeneration and functional recovery. 【Key words】 Comprehensive rehabili