petpresentation-mntp-universityofpittsburgh.pptVIP

Reconstructions of Phantom Data acquired at the University of Michigan Summary PIB retention from two of MCI subjects showed PIB+ results, with significant uptake distributed similarly to that found in subjects with AD. One MCI subject showed PIB- behavior with relatively little PIB uptake. The variability of test-retest was small. Recon/Recon DVR variance was significantly higher than test/retest variance in high PIB uptake areas (high DVR) in PIB+ MCI, while such variances were comparable in lower uptake areas in control and PIB- MCI where PIB uptake was uniformly low. Conclusion Recon/recon variability depends on the degree of regional PIB retention with high levels of uptake showing greater recon/recon variability. Scatter Correction Simulation-based scatter correction: - Analytical simulation: single-scatter simulation: use transmission/emission for calculating single coincidence rate - Monte Carlo simulation: compute scatter estimation from the fundamental physics of the Compton scattering process * Variability of PET-PIB retention measurements due to different scanner performance in multi-site trials Jean-Claude Rwigema Chet Mathis Charles Laymon Jonathan P.J. Carney Tae Kim University of Pittsburgh, Radiology University of Pittsburgh, Medical School Faculty PIB (Pittsburgh Compound B) Amyloid-? (A?) plaque deposition is a pathological hallmark of Alzheimer’s disease (AD) Pittsburgh compound-B (PIB) is a radiotracer used in positron emission tomography (PET) that binds to amyloid plaques and is a valuable tool in the development and evaluation of anti-amyloid therapeutics. Introduction Drug development requires large numbers of research subjects with the concurrent need for large multi-site trials. AD longitudinal studies may be of long duration Different sites may run different software versions Software may be upgraded during a longitudinal study Attenuation image U Mich Reconstruction U Pitt Reconstruction Bone-like Water Air