receptorsreceptortracerskineticmodels.pptVIP

anything tricky about using an in vitro sample for anatomy? what’s the difference between expt 1 and expt 2 in same baboon? why didn’t they estimate BP in 2nd study? Schematic Diagram of Ligand Binding “Rest” condition endogenous NT unlabeled tracer radiolabeled tracer BP = B/F at steady state Schematic Diagram of Ligand Binding “Rest” condition endogenous NT unlabeled tracer radiolabeled tracer loss of receptors BP ↓ Schematic Diagram of Ligand Binding DA-release condition endogenous NT unlabeled tracer radiolabeled tracer DA ↑ BP ↓ DBP is the (fractional) difference in BP between conditions DBP= (BP1-BP2)/BP1 terms for next week: Sept 20 displacement release endogenous simulation what is Logan proving by her simulations? where they get their parameter vals what things might be causing DA release in Koepp expt? what might have been a better control condition(s)? what do (+) changes in binding potential (Fig 2) mean? what is the ‘proof’ that DA release is being measured? what is being optimized in Morris paper? where do they get their parameter vals? * On the left is a photo published in the Baltimore Sun Newspaper on Tuesday Sept 20, 1983, showing Mike Kuhar on left and Henry Wagner on the right. Henry Wagner led the overall PET team, and Mike Kuhar contributed his expertise in labeling receptors in vivo. On the right side is the PET scan of Henry Wagner’s brain. The signatures are, from the center bottom going clockwise, Henry Wagner Jr, Robert Dannals, Joanthan Links, Dean F Wong, Jim Frost, and Mike Kuhar. These are the key individuals in the PET effort at that time. * On the left is a current photo (August 2011) of Mike Kuhar. Mike Kuhar contributed his expertise in labeling receptors in vivo to the Johns Hopkins PET team organized to study receptors. On the right side is the PET scan of Henry Wagner’s brain. The signatures are, from the center bottom going clockwise, Henry Wagner Jr, Robert Dannals, Jonathan Links, Dean F Wong, Jim Frost, and Mike