奥曲肽联合普鲁卡因治疗急性胰腺炎临床疗效的观察.docVIP

奥曲肽联合普鲁卡因治疗急性胰腺炎临床疗效的观察 　　摘要：目的 探讨奥曲肽联合普鲁卡因维持治疗急性胰腺炎临床疗效。方法 将急性胰腺炎患者70例随机分为两组，治疗组、对照组各35例。治疗组常规治疗基础上加30 ug/kg奥曲肽及1%普鲁卡因25 ml 24 h维持治疗；对照组常规治疗基础上加30 ug/kg奥曲肽维持治疗。对比血尿淀粉酶、WBC、血清钙恢复正常时间。且比较腹胀腹痛缓解时间、胃肠功能恢复时间、住院天数。结果 治疗组血淀粉酶、尿淀粉酶、WBC、血清钙等实验室指标优于对照组（P0.05）；治疗组的腹胀腹痛缓解时间、胃肠功能恢复时间、住院天数均比对照组时间短（P0.05），差异具有统计学意义。结论 联合奥曲肽与普鲁卡因维持治疗急性胰腺炎利于改善患者的实验室指标、临床症状及减少住院时间，临床效果明显，值得临床推广应用。 　　关键词：奥曲肽；普鲁卡因；维持治疗；急性胰腺炎 　　Abstract：Objective To explore the clinical effect of octreotide combined with procaine maintenance treatment of acute pancreatitis. Methods 70 cases of acute pancreatitis were randomly divided into two groups， the treatment group and the control group， with 35 cases in each group. The treatment group combined 30ug/kg octreotide with 1 percent of procaine 25ml 24 hours. The control group treated routinely by 30ug/kg octreotide 24 hours. Comparison of serum and urine amylase， WBC， serum calcium recovery time， abdominal distension and pain relief time， gastrointestinal function recovery time， hospitalization days. Results The treatment group， serum amylase， urine amylase， WBC， serum calcium and other laboratory indexes was better than that of the control group （P 0.05）， the treatment group of abdominal distension and pain relief time， gastrointestinal function recovery time， hospitalization time were shorter time than the control group （P 0.05）， the difference was statistically significance. Conclusion Combined octreotide with procaine to improve the laboratory indexes in treatment of acute pancreatitis， the patients clinical symptoms and reduce the time in hospital， the clinical effect is obvious， it is worthy of clinical application. 　　Key words：Octreotide；Procaine；Acute pancreatitis 　　急性胰腺炎（acute pancreatitis，AP）是普外科常见的急腹症之一，其发病机制复杂，表现为胰酶在胰腺激活，炎症反应过度加重胰腺炎病情，各细胞因子互相影响、共同参与胰腺炎的生理、病理过程，介入疾病的发生发展[1]。轻者主要表现为胰腺水肿。重者胰腺出血坏死，出现各种并发症，诱发多器官功能衰竭，临床死亡率居高不下[2]。将我院2011年6月～2014年12月收治的70例急性胰腺炎患者采用奥曲肽联合普鲁卡因维持治疗，现报告如下。 　　1 资料与方法 　　1.1一般资料 本次观察对象共70例，男性47例，女性23例；年龄14～60岁，平均年龄38岁。胆源性胰腺炎