2013-9-17突触传递和调控lb课件.pptVIP

突触后沉默的机制 突触后 AMPA NMDA Glu Glu Mg2+ 膜去极化 AMPA受体的作用机制 沉默突触的功能是什么？ 作为脑学习记忆功能的一种能力储备 谢谢大家 * 思考点：一般和特殊 * * 思考点：功能－形态－分子研究路线 * 突触前膜离子通道分布和类型 以及突触囊泡施放相关蛋白的功能 Neuron 59, September 25, 2008 突触囊泡释放机制 mEPPs provide evidence that synaptic transmission is quantal vesicular Snaptobrebin SNAP-25 Syntaxin Synaptotagmin ?-SNAPS NSF Synapsin I 突触后膜受体和离子通道分布和类型 Activity-dependent trafficking of K+ channels. a Illustration depicting the translocation of several K+ channels in response to common forms of neuronal plasticity. Extrasynaptic KV4.2 channels and KCa2.2 channels located near the postsynaptic densit