Pediatric Drug Development and the Eunice Kennedy Shriver.pptVIP

OUTCOME MEASURES Clinical and Translational Science Awards (CTSA) co-fund with National Center for Research Resources (NCRR) Areas Neurology Cardiovascular medicine Neonatology Topic Areas: 8-neonatology, 5-neurology, 4-hypertension/hypotension, 3-“other”; 1 topic area possible 1 Duke Development of a PK algorithm to improve neonatal outcomes 2 UTHSC Advanced MRI to assess neonatal care and outcome 3 Columbia Targets and Barriers for Hydroxyurea use in Sickle Hemoglobinopathies 4 Utah Improving Management of the Neonatal Abstinence Syndrome 5 U Pitt Cardiac Outcome Measures for Pediatric Muscular Dystrophy UNC Outcome Measures for chronic lung disease of prematurity 7 U-CO Small volume fentanyl PK/PD PG in neonates UC-Davis Outcome Measures for Trials in Children with Autism Vanderbilt Wireless Home-Based Tools for studying sleep in Autism 10 U-MI Pediatric Cardiac Intensive Care Data Standards Repository 11 Stanford Methadone vs. Morphine PD/PD in infants after cardiac surgery 12 Indiana Predictors of Vincristine-induced peripheral neuropathy 13 UAB Nasal Potential Difference Studies Utilizing CFTR Modulators 14 CWRU Efficacy Outcomes Measures in Antihypertensive Trials in Children 15 CWRU Effect of BMI on Exposure-Response Relationships to Lisinopril in Children 16 U-Wash Advancing Patient Reported Outcomes (PROs) in children with Cystic Fibrosis 17 AECOM Pediatric hypertension outcome measures 18 Tufts Improving BPD predictors and outcomes for clinical trials 29 September 2009 * CC-CHOC update Snapshot of BPCA Projects (18 recommended for funding) MT WY ID WA OR NV UT CA AZ ND SD NE CO NM TX OK KS AR LA MO IA MN WI IL IN KY TN MS AL GA FL SC VA WV MI NY PA MD DE NJ CT RI MA ME VT NH AK HI BUILDING A NATIONAL CTSA CONSORTIUM BPCA awardees CTSAs (Sept 2009) Participating Institutions NC OH INFRASTRUCTURE Training in translational/clinical pharmacology Infrastructure to perform pediatric clinical trials INFRASTRUCT