培训课件-高效液相色谱法检测早期胃癌中胃液固有荧光的诊断价值.pptVIP

DISCUSSIONS Amino acid transporters may enhance the transport of amino acids and accumulate aromatic amino acids near cancer foci. The infiltration of excessive aromatic amino acids may significantly increase in gastric juice in EGC compared to NGD. 讨论 氨基酸转运蛋白可能会加强氨基酸的转运和芳香族氨基酸在癌灶周围的积聚。 芳香族氨基酸的过度浸润可能会使其在早期胃癌患者胃液中的含量显著多于良性病变者。 DISCUSSIONS Secondly, aberrant metabolism in cancer cells would precede the visible changes in stomach carcinogenesis. It is known that the abnormalities of amino acid transport and metabolism in a cancerous region occur frequently in the early stage of gastric cancer. 讨论 其次,肿瘤细胞的代谢异常会先于胃癌形成过程中可见的形态学变化。 众所周知,癌变部位氨基酸转运和代谢异常经常发生在胃癌的早期阶段。 DISCUSSIONS Gastric juice, which is generated by the gastric epithelium, contains a substantial amount of information about the metabolic status of the epithelium. Therefore, the information obtained from analysing the gastric juice may be useful in separating biomarkers for the early detection of gastric cancer. 讨论 胃上皮细胞产生的胃液中含有大量的反应上皮细胞的代谢状态的信息。 因此，从分析胃液所获得的信息可能有助于分离出胃癌的早期检测的生物标志物。 DISCUSSIONS Finally, matrix metalloproteinases (MMPs), which are enzymes that degrade the extracellular matrix and basement membrane, play roles in the early phase of tumourigenesis. The over-expression and activity of MMPs accelerates the degradation of extracellular matrix and basement membrane. DISCUSSIONS The degradation of matrix generates aromatic amino acids in the gastric juice surrounding tumour cells. Additionally, blood aromatic amino acids could easily penetrate the impaired basement membrane and epithelia of carcinoma foci and enhance amino acid levels in gastric juice. 讨论 最后，金属基质蛋白酶(MMPs)能降解细胞外基质和基底膜，在肿瘤形成的早期阶段扮演主要角色。 金属基质蛋白酶的过表达和活性增加会加速细胞外基质和基底膜的降解。 讨论 胃液中肿瘤细胞周围细胞外基质的降解会生成芳香族氨基酸。 此外,血液中的芳香族氨基酸可以轻易地穿透受损的基底膜和癌灶的上皮细胞,使胃液氨基酸的水平增高。 DISCUSSIONS These causes could explain the significant enhancement of aromatic amino acids in gastric juice from EGC patients. 讨论 这些原因都可以用于解释早期胃癌患者胃液中芳香族氨基酸的含量显著升高。 CONCLUSION