Buchwald-Hartwig.docVIP

Buchwald-Hartwig Cross Coupling Reaction Palladium-catalyzed synthesis of aryl amines. Starting materials are aryl halides or pseudohalides (for example triflates) and primary or secondary amines. The synthesis of aryl ethers and especially diaryl ethers has recently received much attention as an alternative to the Ullmann Ether Synthesis. Newer catalysts and methods offer a broad spectrum of interesting conversions. Mechanism of the Buchwald-Hartwig Coupling ? Recent Literature [(CyPF-tBu)PdCl2]: An Air-Stable, One-Component, Highly Efficient Catalyst for Amination of Heteroaryl and Ar