chapter (gene10)30.pptVIP

30.1 Introduction The basic principle of regulation is that gene expression is controlled by a regulator that interacts with a specific sequence or structure in DNA or mRNA at some stage prior to the synthesis of protein. Many protein regulators work on the principle of allosteric changes. Regulation via RNA uses changes in secondary structure base pairing as the guiding principle. The changes in RNA structure may result from either intramolecular or intermolecular interactions. The most common role for intramolecular changes is for an RNA molecular to assume alternative secondary structures