Sulfa antibacterials.pptVIP

Discovery of Sulfonamides Prontosil “Red” - Azo-dye Pre-treatment of bacteria before infection, no effect, but subsequent administration to mice - survival! In vivo activity but no in vitro activity! Pro-drug - active in vitro after reduction Sulfanilamide first shown active in vitro by Fourneau (1935) Specific for streptococci not other pathogenic bacteria Only tested in humans by necessity Nobel Prize in 1939 to Domagk Sulfasalazine Sulfonamides - Mechanism of Action Woods (1940) Followed up on observation that bacterial extracts blocked bacteriostatic effects of sulfa Suggested that