细胞穿透肽的研究进展重点讲述.ppt

Background CPPs classification CPPs classification Even though CPPs have a great sequence variety, it is possible to be mainly divided into three subgroups defined by their physical– chemical properties: cationic, amphipathic and hydrophobic。[7] Cationic CPPs Cationic peptides are a class of peptides with a high positive net charge and few acidic amino acid residues.Typical, the cationic CPPs are including R9 , Tat, hLF and (RXR)4 and so on. Amphipathic CPPs Amphiphilic cell-penetrating peptides are composed mainly of lysine 。 There are also distributed to other hydrophilic or hydrophobic amin