24徐萬文乳癖散结胶囊治疗乳腺增生病的疗效观察及机制探讨1.docVIP

乳癖散结胶囊治疗乳腺增生病的疗效观察及机制探讨 湖北省襄樊市第一人民医院普外科 徐万纹 孙金中 摘要 目的: 观察乳癖散结胶囊治疗乳腺增生病的疗效及其对性激素水平的影响。方法: 180例患者按服药时间(1、2、3疗程)随机均分成A、B、C 组。观察各组患者的总有效率、复发率及治疗前后卵泡期血清性激素雌二醇(E2)、孕酮(P)、催乳素(PRL)水平变化。结果: 3组总有效率分别为70%、90%和93.3%；B组、C组患者总有效率明显高于A组(P0.05)，复发率明显低于A组(P0.05)；C组总有效率及复发率与B组比较差异无统计学意义。A组患者治疗后血清E2、P、PRL水平与治疗前比较差异均无统计学意义。B组、C组患者治疗后血清E2、PRL水平较治疗前明显降低(P0.05)，P水平较治疗前明显升高(P0.05)；且B组、C组患者治疗后血清E2、PRL水平较A组患者治疗后明显降低(P0.05)，P水平较A组患者治疗后明显升高(P0.05)。结论: 乳癖散结胶囊治疗乳腺增生病的疗效确切，延长疗程能提高疗效、降低复发率,其机理可能与血清E2、PRL水平下降、P水平上升有关。 [关键词] 乳癖散结胶囊；乳腺增生病；性激素 Clinical observation of therapeutic effect of the treatment of mammary gland proliferation disease with Rupisanjie capsule and mechanism research XU Wanwen, SUN Jinzhong Department of General Surgery, The First Hospital of Xiangfan, Hubei, 441000, China Abstract Objective: To observe clinical effect of treatment of mammary gland proliferation disease with Rupisanjie and research the mechanism. Methods: 180 patients with mammary gland proliferation disease were randomly divided into three groups by different courses of treatment. Their therapeutic effects, the recurrence rate after discontinue of treatment and estradiol(E2)、progestin (P)、prolactin (PRL) were observed and compared. Results: Therapeutic effects of treatment in Group A (total effective rate 90%) and Group B(total effective rate 93.3%) were significantly superior to that in Group A (total effective rate 70%)(all P 0.05), the recurrence rates of Group B(8.3%) and Group C(6.7%) were much less than that of Group A(23.3%) in the follow up(all P 0. 05). There were no statistical differences between the levels of E2、P and PRL in Group A before the treatment and that after the treatment. The levels of E2 and PRL in Group B and in Group C after the treatments were much lower than that before the treatments(all P 0.05)，and the level of P was much higher than that before the treatments(P 0.05). The levels of E2 and PRL in Group B and in Group C after the treatments were much lower than that in Group