培训课件_心衰基本常识.pptVIP

Aldosterone Antagonists Spironolactone, long known for its potassium-sparing diuretic effects, is an aldosterone antagonist, and the only aldosterone antagonist available for clinical use in the US. The RALES study (Randomized Aldactone Evaluation Study), a multi-center mortality trial examined the effect of adding low-dose spironolactone to standard diuretic/ACE inhibitor therapy in HF (NYHA Class III and IV patients) has shown to reduce mortality in heart failure patients1. ACC/AHA Guidelines recommends the use of spironolactone in patients with severe HF. The role of spironolactone in p