酸刺激前后唾液淀粉酶活性, 流率和pH 值的性别差异.docVIP

酸刺激前后唾液淀粉酶活性、流率和pH值的性别差异 杨泽民，林静1，陈龙辉2，张敏3，陈蔚文2，杨小蓉4（510006 广州，广东药学院基础学院1；510405 广州，广州中医药大学脾胃研究所2；510240 广州，广州市海珠区妇幼保健院中医科3；510080 广州，广东药学院附属第一医院检验科4） [摘要] 目的 探讨唾液淀粉酶（sAA）活性、流率和pH值以及sAA活性与流率相关性的性别差异。方法 采集105名健康志愿者酸刺激前后的唾液标本，测定其sAA活性、流率和pH值，分析sAA活性和流率的相关性。结果 （1）柠檬酸刺激能显著增加sAA活性、流率和pH值，其中以流率增加最大；（2）sAA活性、流率和pH值在酸刺激前后以及对刺激的反应（前后的差值）都不存在显著的性别差异；（3）女性在酸刺激前后sAA活性和流率之间以及sAA活性差值和流率差值之间都存在显著的正相关性，并且相关系数相对稳定。然而男性只在酸刺激后的sAA活性和流率之间表现显著的正相关。结论 sAA活性、流率和pH值在基础和应激状态下都没有性别差异，但是sAA活性和流率之间的相关性存在一定的性别差异。 [关键词] 唾液淀粉酶；流率；pH值；柠檬酸刺激；性别 Sex differences of salivary α-amylase activity, flow rate and pH value before and after acid stimulation Zemin Yang1, Jing Lin1, Longhui Chen2, Min Zhang3, Weiwen Chen2, Xiaorong Yang4 (1School of Basic Courses, Guangdong Pharmaceutical University, 510006 Guangzhou; 2Pi-Wei Institute, Guangzhou University of Chinese Medicine, 510405 Guangzhou; 3Pediatrics of Traditional Chinese Medicine, Haizhu Maternal and Child health Hospital, 510240 Guangzhou; 4 Clinical Laboratory, the First Affiliated Hospital of Guangdong Pharmaceutical University, 510080 Guangzhou) [Abstract] Objective To explore sex differences of salivary α-amylase activity (sAA), flow rate, pH value and correlation between sAA activity and flow rate. Methods saliva samples from 105 healthy volunteers were collected before and after citric acid stimulation. The sAA activity, flow rate and pH value were determined for each samples, and the correlation between sAA activity and flow rate was analyzed. Results (1) Citric acid stimulation increased significantly sAA activity, flow rate and pH value, and flow rate had the most increase; (2) No significant sex differences in sAA activity, flow rate and pH value were found in baseline, stimulation and acute responses (delta value) to citric acid stimulation; (3) For female subjects, there were significantly positive correlations between sAA activity and flow rate in unstimulated and stimulated saliva, between sAA activity delta value and flow rate delta val