脑老化ok_培训课件.pptVIP

AF267B (乙酰胆碱受体激活剂) –GSK3β β-Cat 促进增殖 PNZ-乙酰胆碱受体拮抗剂-GSK3β β-Cat 促进凋亡 Fig. 7.乙酰胆碱受体激活剂-AF267B 抑制GSK-3β活性，增加胞质β-Cat immunoprecipitates Western blot and the MTT reduction assay, AF267B- 乙酰胆碱受体激活剂 PNZ-乙酰胆碱受体拮抗剂 MTT Western blot Fig. 7. The GSK-3β activity increase associated to Aβ-neurotoxicity and Wnt/h-catenin signaling inhibition is prevented by M1 mAChR activation in hippocampal neurons. (A) Cells were co-treated with 5 μM Aβwith or without 10 μM AF267B in the presence or absence of 10 nM PNZ. GSK-3h activity was measured in GSK-3h immunoprecipitat