OPG,RANKRANKL系统对骨质疏松症的影响.docVIP

OPG/RANK/RANKL系统对骨质疏松症的影响 【摘要】：目前骨质疏松发病率居常见病 多发病的第7位，是中老年常见疾病。而OPG/RANKL/RANK系统的研究成果是近几年骨生物学领域所取得的重大突破之一，其作为破骨细胞分化、成熟和骨吸收调节的关键调节物，对于明确骨质疏松的形成机理具有重要的意义，对该系统的深入研究将为骨质疏松的预防及靶向治疗提供积极而深远的意义。 【关键词】：OPG/RANK/RANKL系统 骨质疏松 破骨细胞 【summary】At present,osteoporosis(OP) is a common disease in the middle-aged and elderly, the morbidity of which ranks 7th in common diseases and frequently-occurring diseases.The research result of the OPG/RANKL/RANK system is one of the major breakthroughs of bone biology in recent years.As a key part of osteoclast differentiation,maturation and bone resorption regulation,the