药物化学capter4.pptVIP

Key Issues of Lead Discovery Means Chapter4 Natural Products Acquisition and extraction Species, parts, location and season Protocol for extraction Screening methods Isolation of active compounds Chromatography, HPLC Structure elucidation NMR, MS, X-ray Further biological assessment Large-scale supplies Other resources, (semi)synthesis, tissue culture, gene engineering Structure-activity relationships Natural products based combichem gene engineering Penicilin morphine purvalanol SemiSynthesis Total synthesis Combinatorial Chemistry (I) It is a synthetic technique to prepare sets of comp