Effecs of Obstructive Sleep Apnea and Obesity.docVIP

J Clin Endocrinol Metab. 2014 Feb; 99(2): 656–663. Published online 2013 Nov 25.?doi:??10.1210/jc.2013-3327 PMCID:?PMC3913804 Lipopolysaccharide-Binding Protein Plasma Levels in Children: Effects of Obstructive Sleep Apnea and Obesity Leila Kheirandish-Gozal,?Eduard Peris,?Yang Wang,?Maximiliano Tamae Kakazu,?Abdelnaby Khalyfa,?Alba Carreras, and?David Gozal Section of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, Illinois 60637 Corresponding author. Address all correspondence and requests for reprints to: Leila Kheirandish-Gozal, MD, MSc, or David Gozal, MD, Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue/MC2117, Chicago, IL 60637-1470. E-mail:?ude.ogacihcu.dsb.sdep@lazogl; or?;?Email:?ude.ogacihcu@lazogd. Received 2013 Aug 29; Accepted 2013 Nov 11. Copyright?? 2014 by The Endocrine Society Abstract Background: Obstructive sleep apnea (OSA) has been linked to obesity, inflammation, and metabolic syndrome. The gut microbiota, which serves as reservoir for bacterial lipopolysaccharides (LPS), could be altered by OSA and trigger inflammation. LPS-binding protein (LBP) serves as a surrogate marker of underlying low-grade endotoxemia by LPS from the gut. We hypothesized that systemic LBP levels would be higher in obese children and in those with OSA. Methods: Consecutive snoring and nonsnoring children (mean age 6.8 ± 1.3 y) were included after overnight polysomnography, and fasting levels of lipids, insulin glucose, and high-sensitivity C-reactive protein were obtained. Children were subdivided into four subgroups based on the presence of obesity or OSA. Plasma LBP levels were assayed using ELISA. Results: Of 219 participants, nonobese controls had the lowest levels of LBP, and the presence of obesity without OSA was associated with significant LBP increases. Nonobese children with O