第二章 有合成设计逻辑推理201403.ppt

含有给电子基团的亲二烯物，反应难以进行。 单独的二烯和亲二烯物也难反应。 环中的双烯 分子内DA反应 Retron of Diels-Alder Tf由此可见，D-A转换会有很多种，这样的Retron就会有许多回推结果，像这样的Retron，Corey称之为Supra Retron。A stuctural subunit in target molecule which consists not only of a complete retron for a particular transform but also of additional structural elements which signal the applicability and effectiveness of that transform. A supra retron contains ancillary keying group in addition to those of the basic or minimal retron. Catalytic Hydrogenation Tf Simmons-Smith TfTGT中并没有Retron，虽有六员环但没有了双键。但是如果再利用一些Tf将之转变一下，就会出现Retron，而容易回推。像这样的情况，Corey称之为Partial Retron（不