抗真菌药物长沙讲稿吴安华_培训课件.pptVIP

* Caspofungin is approved for second line therapy of invasive aspergillosis and for esophageal candidiasis, and voriconazole for first line therapy of aspergillosis and for second line therapy of fusariosis and scedosporidiosis * * * - Halflife 20 uur laat toe om 1x per dag te doseren, maar betere AUC werd bekomen door de dosis in 2 te splitsen door betere absorptie * * *药事质控中心 中南大学湘雅医院吴安华 * 伏立康唑 TDM? TDM … 所有患者?进展性感染患者？明显视力或肝毒性患者？ 在有血药浓度波动危险的患者? 药物相互作用? 肝肾功能变化? 口服治疗? ICU? 每日(cost-effectiveness)? 方法? 剂量调整?非线性关系! Goodwin M et al. JAC 2007. Epub药事质控中心 中南大学湘雅医院吴安华 * 帕沙康唑 抗