- 1、本文档共25页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Systemic Lupus Erythematosus Doctor NaLi Bin zhou medical college Yantai affiliated hospital SLE Autoimmune disease that affects multisystems 1.5 million cases of lupus Prevalence of 17 to 48 per 100,000 population Women Men - 9:1 ratio 90% cases are women African Americans Whites Onset usually between ages of 15 and 45 years, but Can occur in childhood or later in life Clinical Manifestations For the purpose of identifying patients in clinical studies, a person has SLE if 4 or more of the 11 criteria are present, serially or simultaneously, during any interval of observation. (specificity 95%, sensitivity 75%) It is important to remember that a patient may have SLE and not have 4 criteria. Criteria Butterfly rash Discoid lupus Photosensitivity Oral ulcers Arthritis Serositis 7. Neurologic d/o 8. Hematologic d/o 9. Renal d/o 10.Immunologic: anti-DNA, anti-Sm, false pos STS 11.Anti-nuclear antibody Cutaneous Most common rash is photosensitive, raised erythematous malar rash. 55-85% develop at some point in disease Discoid Lupus Erythematosus (DLE): 15-30% circular, scaly hyperpimented lesions with erythematous rim, atrophic center—can be disfiguring Mouth/vaginal/nasal ulcers Alopecia: may be diffuse or patchy. Occurs 50% Malar Rash Discoid Rash Oral Ulcers MSK Polyarthritis, mild to disabling, occurs most frequently in hands, wrists, knees. Occurs 90% Joint deformities occur in only 10% Arthritis of SLE tends to be transitory If single joint has persistent pain, consider osteonecrosis (prevalence increased in SLE over general population, especially if on steroids.) Myositis with elevated CK and weakness rarely occurs Arthritis Serositis - Pulmonary Pleuritis with or without effusion - if case is mild, tx: NSAIDS - if case is severe, tx: steroids Life-threatening manifestations: interstitial inflammation which can lead to fibrosis and intra-alveolar hemorrhage. Also pneumothorax and pulmonary HTN can occur Serositis – Cardiac Pericarditis: most
您可能关注的文档
最近下载
- 再保险电子教案省公开课一等奖全国示范课微课金奖PPT课件.pptx
- 江苏省政府采购评审专家考试题库.docx VIP
- 2024届高考英语二轮专题复习与测试专题六读后续写课件(共94张PPT).pptx
- 酒店运营管理(北京联合大学)中国大学MOOC慕课章节测验答案(课程ID:1206458820).pdf
- 小塞尔采蓝莓儿童故事绘本PPT课件.ppt VIP
- 《百草枯中毒》ppt课件.pptx
- 一年级奥数教材详细版.doc
- 专题04 一次函数中的特殊平行四边形存在性问题(原卷版)-2024年常考压轴题攻略(9年级上册人教版).pdf
- 关于江苏省政府采购评审专家.doc VIP
- Unit 5 Lesson 3 At the zoo 课件 七年级英语上册冀教版(2024).pptx VIP
文档评论(0)