Chapter 2 Immune organs and Tissues课件.ppt

* TEC---thymus epithelial cell MΦ---macrophage DC----dendritic cell * PALS---periarteriolar lymphoid sheaths * MIS---mucosal immune system MALT---- mucosal-associated lymphoid tissue    Chapter 2 Immune organs and tissues 第二章 免疫器官与组织 Immune organs is called lymphoid organs. Immune organs are divided into Central and peripheral immune organs 中枢与外周免疫器官 Central immune organs :thymus and bone marrow peripheral immune organs :spleen, lymphonodes and mucosal-associated lymphoid tissue § 1 Central Immune Organs 第一节 中枢免疫器官 Central immune organ are composed of Bone marrow（骨髓）and Thymus（胸腺） a place for generation, differentiation, development and maturation of immune cells(B T) 一、bone marrow （骨髓） （一）structure ：结构 1).Stromal cells （基质细胞）composed with microenvironment,HIM=Soil（土壤） 异常时可导致骨髓增生异常综合症（MDS） 2).Hematopoietic stem cell（造血干细胞）= Seed（种子） 异常时可导致白血病 (lymphoid stem cell and myeloid stem cell in the bone marrow） (二) Differentiation of HSC and Immune cell form（ 造血干细胞与免疫细胞分化发育） 1、 Origin of HSC 造血干细胞分化发育 yolk sac? fetal liver、 spleen ? bone marrow 起源于卵黄囊，途径肝脾，定位于骨髓 pluripotent hematopoietic stem cell ( self-renewing and differentiation) ?lymphoid progenitor and myeloid progenitor ? develop into Mature T cells in thymus,B cells in bone marrow 2、surface marker of HSC 造血干细胞的表面标志 1)、CD34： CD34 express in 1-4% bone marrow cells ，and is a characteristic marker in HSC，but mature T cells CD34－ Immune magnetic bead,IMB/ Fluores activated cell sorting,FACS 2)、CD117（c-kit）：It is stem cell factor receptor (SCFR ) from c-kit gene.CD117+ cells account for 1-4%,IgSF.50-70% CD117+ cells express CD34+，It is a characteristic marker in HSC 3)、Lin- cell：lineage negative cells,Lin-：non-marker early HSC。CD2 CD3/ T；CD19、CD24/B；CD14/M；CD16、56/NK；Antibody-A/RBC ---mixture antibody+IMB----HSC （三）Function of bone marrow 骨髓的功能 1、generation p