医学免疫学-01课件.pptVIP

* * * 又称为血清型，Ig可以与抗原发生特异性结合，但其本身又是蛋白质分子，包含有多种不同的抗原表位，呈现出不同的免疫原性，可以激发机体产生特异性免疫应答，产生抗同种型/同种异型抗体和抗独特性抗体 。Ig分子上有三种不同的抗原表位：同种异型是由于同一种属内不同个体之间的个体差异引起的。 * Allelic variation within a species that leads to minor, but detectable differences in constant regions between strains * Ig特殊的基因结构 * In the case of the heavy chain…，In naive, mature B cells, the primary mRNA transcript contains VDJ and BOTH Cm and Cd. This primary transcript can be differentially processed to give rise to mRNA encoding either IgM or IgD. This explains why naive B cells express both IgM and IgD. The variable region of both are