胆碱对心血管疾病风险评估意义的Meta分析.docVIP

胆碱对心血管疾病风险评估意义的Meta分析 　　摘要：目的 对近年来国内外发表的不同膳食胆碱水平对心血管疾病发病风险的文献进行Meta分析，探讨胆碱和心血管疾病之间的关系。方法 以“choline”、“plasma choline”、“whole-blood choline”、“serum choline”、“cardiovascular disease”、“cerebrovascular disease”、“acute coronary syndrome”、“dyslipidemia”、“hypertension”、“atherosclerosis”、“transient ischemic attack”、“stroke”、“acute ischemic stroke”、“rheumatic heart disease”、“coronary heart disease”和“peripheral artery disease”等为检索词。利用PubMed、Ovid、Embase、维普、中国知网等电子数据库进行检索。并同时运用了手工检索和文献追溯的检索手段。收集国内外2000～2015年9月公开发表的关于胆碱与心血管疾病关系的研究，两名评价者独立依据纳入和排除标准筛选文献，提取资料并进行方法学质量评估。统计学分析采用RevMan 5.3软件。结果 共纳入5个研究。Meta分析结果表明，摄入不同的胆碱水平，其冠心病、脑卒中、心肌梗死和外周动脉疾病结局发生的风险比较差异均无统计学意义[RR=1.10，95%CI（0.97，1.25），P=0.15]。结论 膳食胆碱摄入水平和心血管疾病的发生风险无关。 　　关键词：膳食胆碱；心血管疾病；Meta分析 　　Abstract：Objective A meta-analysis of the effect of choline level upon the risk of CVD estimated in home and abroad studies was conducted to evaluate the effect of choline level upon the prevention and treatment of CVD.Methods Searching keywords included “choline”，“cardiovascular disease”，“cerebrovascular disease”，“acute coronary syndrome”，“dyslipidemia”，“hypertension”，“atherosclerosis”，“transient ischemic attack”，“stroke”，“acute ischemic stroke”，“rheumatic heart disease”，“coronary heart disease”and“peripheral artery disease”. Clinical data were retrieved from PubMed，Ovid，Embase，Chongqing VIP，CNKI databases. Manual searching and literature retrieval were employed. Studies analyzing the relationship between dietary choline level and CVD，published between 2000 and September 2015，were retrospectively collected. Clinical data were extracted and methodology quality evaluation was conducted by two independent experts based upon inclusion and exclusion criteria. Statistical analysis was performed by using RevMan 5.3 software.Results Five studies were included. Meta-analysis results demonstrated that the incidence of coronary heart disease （CHD），stroke，myocardial infarction and peripheral artery disease （PAD） did not significantly vary according