2型糖尿病伴非酒精性脂肪肝的临床分析.docVIP

2型糖尿病伴非酒精性脂肪肝的临床分析 　　[摘要] 目的 探讨2型糖尿病伴非酒精性脂肪肝（NAFLD）的临床特点。 方法 选取84例2型糖尿病伴NAFLD患者，另选取74例非NAFLD 2型糖尿病患者，比较分析两组患者的一般资料及生化指标。 结果 伴NAFLD组患者的胰岛素抵抗指数（HOMA-IR）、腰围（WC）、体重指数（BMI）、三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、尿酸（UA）、天冬酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、γ-谷氨酰转移酶（GGT）均明显高于非NAFLD组（P＜0.05）；伴NAFLD组患者的高密度脂蛋白胆固醇（HDL-C）低于非NAFLD组（P＜0.05）。 结论 2型糖尿病伴NAFLD与胰岛素抵抗有密切联系，临床应加强对体重、血糖、血脂、尿酸的有效控制，纠正代谢紊乱，改善胰岛素抵抗。 　　[关键词] 2型糖尿病；非酒精性脂肪肝；胰岛素抵抗 　　[中图分类号] R587.1[文献标识码] B[文章编号] 1674-4721（2014）04（c）-0180-02 　　 　　Clinical analysis of type 2 diabetes with nonalcoholic fatty liver 　　CHEN Fu 　　Department of Endocrinology,the First Affiliated Hospital of Shantou University Medical College,Guangdong Province,Shantou 515041,China 　　[Abstract] Objective To investigate the clinical features of type 2 diabetes with nonalcoholic fatty liver. Methods 84 patients with type 2 diabetes and NAFLD and 74 patients with type 2 diabetes were selected,general information and biochemical parameters of two groups were compared. Results In the NAFLD group,insulin resistance index (HOMA-IR),waist circumference (WC),body mass index (BMI),triglyceride (TG),total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C),uric acid (UA),aspartate aminotransferase(AST),alanine aminotransferase(ALT),γ-glutamyl transferase (GGT) were significantly higher than those in the non-NAFLD group (P0.05).High-density lipoprotein cholesterol (HDL-C) in NAFLD group was less than that in the non-NAFLD group (P0.05). Conclusion The realationship between type 2 diabetes with NAFLD and insulin resistance are closely,we should strengthen clinically effective control of body weight,blood glucose,cholesterol,uric acid,correct metabolic disorders and improve insulin resistance. 　　[Key words] Type 2 diabetes;Nonalcoholic fatty liver;Insulin resistance 　　随着社会经济的发展、人们饮食结构的改变，2型糖尿病患者日益增加，其中合并非酒精性脂肪肝（nonalcoholic fatty liver，NAFLD）患者也日益增加，若不引起足够重视，则可能导致肝硬化，最终发展为肝衰竭[1]。本研究就2型糖尿病伴NAFLD存在的危险因素及临床意义进行探讨，以期为临床治疗提供依据。 　　1 资料与方法 　　1.1 一般资料 　　选取本院2012年