腰椎间盘突出症髓核组织中磷脂酶A2的表达与神经根性疼痛的关系.docVIP

腰椎间盘突出症髓核组织中磷脂酶A2的表达与神经根性疼痛的关系 　　[摘要] 目的 探讨腰椎间盘突出症中磷脂酶A2的表达及与神经根性疼痛的关系。 方法 选择80例腰椎间盘突出症伴神经根性疼痛患者，根据神经根性疼痛程度分为四组（I级、II级、III级、IV级），每组20例。采用ELISA法检测腰椎间盘患者髓核组织中磷脂酶A2水平，分析后者与患者神经根性疼痛的关系。并取同期20例腰椎骨折手术患者正常腰椎间盘进行对照。 结果 ①腰椎间盘突出症患者髓核组织磷脂酶A2的表达均比正常对照组增高（PIII级II级I级（P0.05）。 结论 腰椎间盘突出症患者髓核组织磷脂酶A2的表达比正常椎间盘明显增加；髓核组织中磷脂酶A2水平增高可能在腰椎间盘突出神经根性疼痛中起重要作用。 　　[关键词] 腰椎间盘突出症；磷脂酶A2；神经根性疼痛 　　[中图分类号] R681.530.2 [文献标识码] A [文章编号] 1674-0742（2013）06（c）-0026-02 　　Expression of Phospholipase A2 in the Nulcei Pulposus of the Lumbar Disc herniation and its Relation to the Sciatic pain. 　　ZHANG Zhenqian KONG Zhiqiang CHENG Benqiang LONG Chaoyi 　　Zhaoqing first people’s hospital， Zhaoqing 526020， Guangdong Province， China 　　[Abstract] Objective To explore the expression of Phospholipase A2 （PLA2） in the nulcei pulposus of the lumbar disc herniation （LDH） and its relation to the sciatic pain. Methods Eighty patients diagnosised with LDH and another twenty patients diagnosised with bursting fracture of lumbar spine （BFLS） were selected. The LDH patients were divideded into four groups according to the severity of sciatic pain each contained 20 patients：Grade I， II， III and IV. The PLA2 activity was detected by EIISA in the nulcei pulposus obtained at surgery for disc hernition. Another 20 normal nulcei pulposus from patients suffering from BFLS were obtained and analyzed by the same procedure as a control group. Results ①The level of PLA2 in LDH patients were higher than control group （P0.05）；②The level of PLA2 in LDH increased with the severity of sciatic pain. Conclusion The expression of PLA2 in the nulcei pulposus of LDH patients were significantly higher than the control group. The increase of PLA2 activity in the nulcei pulposus was well correlated with the severity of sciatic pain. 　　[Key words] Lumbar disc herniation （LDH）； Phospholipase A2 （PLA2）； Sciatic pain 　　腰椎间盘突出症是引起腰腿痛的常见原因[1]。导致神经根性疼痛的直接原因常认为是腰椎间盘的机械性压迫。但是，随着目前不断深入研究腰椎间盘，多数学者[2]认为椎间盘退变不仅是一种生物力学现象，生物化学机制也可能起着重要作用。但是，生物化学的确切机制至今仍存