《放疗联合化疗治疗脑转移.pptVIP

放疗联合TKI治疗肺癌脑转移 山东肿瘤医院 李宝生 Gefitinib enhanced radiosensitivity of tumor cells -percentage of S phase decreased after Iressa Iressa+RT Gefitinib speeds up apoptosis of tumor cells after RT Gefitinib inhibits RT induced damage repair (Western blot) --Iressa+RT (Western blot) WBI+Gefitinib治疗 NSLC脑转移 Four (19%) and 13 patients (62%) :CR and PR MPFS and OS: 10.0 months (95% CI: 7.5–12.5 months) and 13.0 months (95% CI: 8.2–17.8months) The most frequent toxicities included rash (86%) and diarrhea (43%), with only 3 patients developing a grade III diarrhea Gender and cigarettes/year were predictive factors for the responses found in univariate analysis All domains of QoL were significantly improved following treatment Target accurately 广而告之 欢迎参加 国家继续教育项目 -肺癌规范化治疗学习班 时间：2013年8月1日-3日 地点：青岛 学分：国家I类继续教育学分10分 Ma SL. Lung Cancer, 2008 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. EGFR TKI敏感突变和生存 中位生存期: 有敏感突变17.5月（10.9-24.0） 野生型和非敏感突变病人的13.9月（10.7-17.1） Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. * TKIs可能有放疗增敏作用。 TKIs与放疗联合在脑转移的治疗中是否优于TKIs单药—May be？联合的方式？有待积累更多数据。 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. 谢 谢 ! 祝大家身体健康 工作顺利 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Microglial cell 小胶质细胞 Dormant tumor cell：休眠肿瘤细胞 * 血脑屏障是机体参与固有免疫的内部屏障之一，能阻挡病原生物和其他大分子物质由血循环进入脑组织和脑室。 在血管内皮和基板之间的散在分布的一种扁平而有突起的细胞叫周细胞（pericyte） 血脑屏障是指脑毛细血管阻止某些物质（多半是有害的）由血液进入脑组织的结构。血液中多种溶质从脑毛细血管进入脑组织，有难有易；有些很快通过，有些较慢，有些则完全不能通过，这种