第4章-以酶为靶点的药物设计.pptVIP

* Medicinal Chemistry * 2.3 The Active Site of Neuraminidase Fig 4. The active site of NA Biochemistry, 2001, 42:718-727 Fig 5. The “airplane” model of NA active site J Med Chem, 2003,44(8):1192-1201 Babu et al demonstrated that what is important for potent NA inhibition is not the absolute position of the central ring but rather the relative positions of the interacting groups. “Using structural information about drug targets or their natural ligands as a basis for the design of effective drugs.” positive charge and hydrogen bonding environment negative charged region small hydrophobic re