Takotsubocardiomyopathyaftertreatmentofpulmonaryarterialhypertension.docVIP

Takotsubo cardiomyopathy after treatment of pulmonary arterial hypertension David P. Cork, Amit K. Mehrotra, and Mardi Gomberg-Maitland Department of Cardiology, University of Chicago, Chicago, IL, USA Address correspondence to: Dr. David P. Cork University of Chicago, 5841 South Maryland Avenue, MC 3051, Chicago, IL 60637, USA ; Email: davidpcork@ Author information ? Copyright and License information ? Copyright : ? Pulmonary Circulation This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Go to: Abstract Pulmonary arterial hypertension is a fatal disease. Intravenous prostanoids are often utilized for long-term management of patients. The therapy requires a significant commitment and change in lifestyle for both the patient and family. Takotsubo cardiomyopathy, transient apical ballooning syndrome, has been reported in association with emotional and physical stress. This case report describes a patient with pulmonary arterial hypertension who developed Takotsubo cardiomyopathy after treatment initiation with intravenous treprostinil [tr?pr??st?n?l] 曲前列环素. Over time, the syndrome resolved and the patient had return of normal left ventricular function. Takotsubo cardiomyopathy should be recognized as a potential, rare complication of therapy initiation due to the severity of the illness and the emotional stress of the disease. Keywords: pulmonary hypertension, takotsubo cardiomyopathy, treprostinil Transient left ventricular apical ballooning syndrome, or Takotsubo cardiomyopathy, is characterized by acute chest pain, electrocardiographic changes, elevated cardiac enzymes, and the absence of significant epicardial coronary artery disease.[1] Though numerous published reports have proposed pathophysiologic mechanisms,[2] no clear mechanism has been identified. Num