氯诺昔康片对痛风性关节炎镇痛效果及安全性观察.docVIP

氯诺昔康片对痛风性关节炎镇痛效果及安全性观察 　　[摘要] 目的 探讨氯诺昔康片对痛风性关节炎的镇痛效果及安全性。 方法 选择2010年10月～2013年10月台州市黄岩区城区社区卫生服务中心骨科门诊痛风性关节炎患者114例，将其随机分为观察组和对照组，各57例。对照组给予布洛芬缓释胶囊1粒/次，2次/d，疗程2周；观察组采用氯诺昔康片8～16 mg/次，2次/d，疗程2周。2周后评价疗效，比较两组疼痛积分及不良反应。 结果 观察组有效率为96.5%；对照组有效率为78.9%，差异有高度统计学意义（χ2=20.178，P 0.01）；治疗后，观察组疼痛积分为（2.76±1.27）分，对照组疼痛积分为（3.94±1.19）分，差异有高度统计学意义（t = 5.50，P 0.01）。两组不良反应比较，对照组腹痛3例，呕吐2例；观察组无出现腹痛，呕吐1例。 结论 氯诺昔康片治疗痛风性关节炎镇痛效果确切，且不良反应少，值得临床推广应用。 　　[关键词] 氯诺昔康片；痛风性关节炎；疗效；疼痛积分 　　[中图分类号] R589.7 [文献标识码] A [文章编号] 1673-7210（2014）08（c）-0084-04 　　Observation on efficacy and safety of Lornoxicam Tablets in treatment of gouty arthritis 　　YUAN Zhi1 MOU Zhe1 YUAN Qiuwen2 ZHU Rangteng2 GUAN Minchang2 　　1.Huangyan District Community Health Service Center in Taizhou City， Zhejiang Province， Taizhou 318020， China； 2.Luqiao Hospital of Taizhou Enze Medical Center， Zhejiang Province， Taizhou 318050， China 　　[Abstract] Objective To observe the efficacy and safety of Lornoxicam Tablets in treatment of gouty arthritis. Methods 114 patients with gouty arthritis in Department of Orthopaedics of Huangyan District Community Health Service Center in Taizhou City from October 2010 to October 2013 were randomly divided into control group （n=57） and the observation group （n=57）. Ibuprofen Sustained-Release Capsules were taken by patients in control group， 1 pills each time， 2 times a day， on 2 successive weeks. Lornoxicam Tablets were taken by patients in observation group， 8～16 mg each time， 2 times a day， on 2 successive weeks. After 2 weeks， therapeutic effects， the pain scores and adverse reactions were compared. Results In the observation group， the effective rate was 96.5%， while in the control group， the effective rate was 78.9%， there was a significant difference in therapeutic effect between the observation group and the control group （χ2=20.178， P 0.01）. After treatment， the pain score was （2.76±1.27） points in the observation group and （3.94±1.19） points in the control group， there was a significant