Collective Brownian Motors Experiments and Models集体布朗马达实验和模型.pptVIP

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Collective Brownian Motors Experiments and Models集体布朗马达实验和模型.ppt

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Collective Brownian Motors - Experiments and Models Erin Craig, Heiner Linke University of Oregon Slow motion Average velocity peaks at L ≈ 5 s, independent of polymer length N. Stall force is proportional to polymer length high-speed video works for all liquids tried, nitrogen, water, acetone, methanol, ethanol (wide range of boiling points) droplet hovers on a vapor cushion 10=100micron thick, when surface much hotter than liquid boiling point droplets on sawtooth accelerate to right , vapor flow exerts viscous force on droplet, pulling it This movie helps visualize the vapor flow, using glitter particles that were scattered on the surface. Myosin V: 3D model pair of IQ motifs treated as rigid element flexibility at joints hinge between neck domains myosin head harmonic rotation about state-dependent equilibrium angle neck domain Myosin V 3D model: elasticity of neck domains Neck domain: 3 rigid segments flexibility at joints M. Terrak et. el., PNAS 102, 12718 (2005). M. Doi and S. F. Edwards, “The Theory of Polymer dynamics”, (1986). Bending energy of semiflexible filaments: r′3 r1 r′1 r′2 r2 r3 r0 r′0 A Q i j k r0 Myosin V 3D model: rotational states Post-stroke: Pre-stroke: ADP-bound Empty ATP-bound QB x z y r1 ADP.Pi-bound QA y x z r1 y x r1 f = 0 “Bird’s eye” view: Myosin V 3D model: mechanical cycle ATP ADP ADP ATP ADP·Pi ADP ADP ADP ADP 4. 5. 1. 2. 3. ATP Pi ADP Myosin V 3D model: mechanical cycle ATP ADP ADP ATP ADP·Pi ADP ADP ADP ADP 4. 5. 1. 2. 3. ATP Pi ADP r1 r′1 QA QB I Myosin V 3D model: mechanical cycle ATP ADP ADP ATP ADP·Pi ADP ADP ADP ADP 4. 5. 1. 2. 3. ATP Pi ADP r1 r′1 QA QB I r1 r′1 QA QA II Myosin V 3D model: mechanical cycle ATP ADP ADP ATP ADP·Pi ADP ADP ADP ADP 4. 5. 1. 2. 3. ATP Pi ADP r1 r′1 QA QB I r1 r′1 QA QA II r′1 QA III ATP ADP ADP ATP ADP·Pi ADP ADP ADP ADP 4. 5. 1. 2. 3. ATP Pi ADP Myosin V 3D model: mechanical cycle ATP ADP ADP ATP ADP·Pi ADP ADP ADP ADP 4. 5. 1. 2. 3. ATP Pi ADP Myosin V 3D model: mechanical cycle ATP AD