抗甲状腺药物治疗孕妇甲腺功能亢进的疗效以及对胎儿的影响抗甲状腺药物治疗孕妇甲状腺功能亢进的疗效以及对胎儿的影响.docx

抗甲状腺药物治疗孕妇甲状腺功能亢进的疗效以及对胎儿的影响【摘要】目的：探讨抗甲状腺药物治疗孕妇甲状腺功能亢进的疗效以及对胎儿的影响。方法：将70例甲状腺功能亢进的孕妇按照是否接受抗甲状腺药物治疗分为两组，研究组和对照组，研究组孕妇给予抗甲状腺药物治疗，而对照组孕妇拒绝接受抗甲状腺药物治疗。观察并比较两组患者的疗效以及胎儿的发育情况。结果：研究组孕妇足月顺产30例，早产5例；对照组孕妇流产或死胎15例，足月顺产15例，早产5例。两组新生儿在性别、胎龄、出生体重等反面比较差异均无统计学意义（均P＞0.05）。研究组患者总有效率为77.14%（27/35）；显著高于对照组的28.57%（10/35）（P＜0.05）。研究组和对照组新生儿FT3、FT4、TT4水平没有显著差异（均P＞0.05）。结论：抗甲状腺药物治疗孕妇甲状腺功能亢进可显著促进孕妇的健康，且对胎儿无明显副作用。【关键词】抗甲状腺药物；孕妇；甲状腺功能亢进；疗效；胎儿Effect?of anti thyroid drug?in treatment of pregnant women with hyperthyroidism?and its effects on the fetus[Abstract]?Objective: To study the effect?of anti thyroid drug in treatment of pregnant women with?hyperthyroidism?and?the effects on the fetus.?Methods: 70 cases of pregnant women with hyperthyroidism?were divided into two groups,?the study group and the control group,?according to?whether or not to accept theantithyroid drug?for treatment,?the pregnant women?in the study group were given?anti thyroid?drug for treatment?while the pregnant women in the control group?refused to accept theantithyroid drug for treatment.?The efficacy and?the development of the fetus were observed andcompared between the two groups of?patients.?Results:The study group?had 30 cases of?full-termpregnant women,?5 cases of premature labor;?the control group had 15 cases of?miscarriage or?stillbirth,?15?cases of?full-term normal delivery,?5 cases of preterm labor.?Two?groups of neonates?had no statistical significance difference?in gender,?gestational age,?birth weight?and so on?(P0.05).?The total effective rate of the study group?was 77.14%?(27/35), significantly higher than28.57% (10/35)of the control?group (P0.05).?The study group and the control group?had no significant difference?(P0.05)in FT3,?FT4,TT4?level.?Conclusion:Antithyroid drug?can significantly promote the?health of pregnant women with the?hyperthyroidism?and it has no obvious side effects?on the fetus.[keywords]?anti?thyroid drugs;?pregnancy;?hyperthyroidism;curative effect;?Fetus甲状腺功能亢进是由多种原因综合作用而引起的甲状腺分泌甲状腺激