MicroRNA-DirectedCleavageofHOXB8mRNA.pptVIP

MicroRNA-Directed Cleavage of HOXB8 mRNA Soraya Yekta,I-hung Shih, David P.Bartel 23 APRIL 2004 VOL 304 SCIENCE Hox genes in mammals The vertebrate homeotic complex comprises four distinct Hox gene clusters (Hox A, B, C, D) that are organized into thirteen homology The chromosomal organization of the genes in each Hox cluster reflects its anterior-posterior expression in the body plan (spatial colinearity). In general, members of the same subgroup are expressed at the same time and have the same anterior boundary of expression Recent progress In plant, mos