非甾体抗炎药物与老年性上消化道溃疡的关系.docVIP

非甾体抗炎药物与老年性上消化道溃疡的关系【摘要】 目的 探讨非甾体抗炎药物对老年人胃粘膜损害与溃疡病发生的相互关系。方法 统计我院干部病房XX年6月～XX年6月60～94岁上消化道内镜检查者1213例，其中服用NSAID组612例,非服药组601例,对两组溃疡病发生率行对照分析。结果 612例NSAID组上消化道溃疡发生率16.01%（98/612），非NSAID组上消化道溃疡发生率3.66%（22/601），服用时间越长，消化道溃疡发生率越高，统计结果12.35%，与国内统计15%-30%近似。结论 非甾体抗炎药物对老年人胃粘膜损害高于非服用NSAID组。 【关键词】 消化性溃疡 消炎药 非甾类 【Abstract】Objective: To determine the relationship between nonsteroidal anti-inflammatory drugs (NSAID) and the gastric mucosa lesion in the old age. Methods: 1213 patients, who examined by the superior gastrointestinal endoscope from June XX to June XX, were analyzed in 60 to 90 old from our department. 612 cases were treated with non-steroidal anti-inflammatory drug, others were not taken medicine. The incidence rates of the canker were compared in two groups. Results: The incidence rates of the upper digestive tract canker was16.01%（98/612）and 3.66%（22/612）respectively in NSAID and non- NSAID groups, the longer NSAID were taken the higher incidence rates of the canker. The lesion of gastric mucosa rate was 12.35%, which was higher in NSAID group than that of in non-NSAID group for old age，it is higher similar to compare with the internal statistics(15%-30%).Condusion:Non-steroidal anti-inflammatory drugs on gastric damage than NSAID group. 【Key words】Peptic ulcer Antibiotic medicine Non-sterides 非甾体抗炎类药（Non-steroidal anti-inflammatory drugs NSAID），是临床上应用较广泛的一类药物。NSAID有多种不良反应，其中最常见的是上消化道粘膜损害和消化道溃疡[1]。本文通过上消化道内镜、食管胃粘膜病理，详细观察一组服用NSAID的老年人群并与未服用NSAID的患者进行对照，现分析如下。 1 资料与方法 1.1 临床资料 统计我院干部病房XX年6月-XX年6月老年患者进行上消化道内镜检查1213例，其中男性1107例，女性106例，年龄60-94岁，平均69.2岁。详细询问病史、服用药物种类及服药时间，将胃镜检查1213例分为非甾体抗炎药组（1组）612例和未服用非甾体抗炎药物组（2组）601例，进行统计分析。 1.2 采用OLYMPUS 240.260型电子胃镜，观察粘膜的改变及溃疡的部位，并取活检4-6块行病理检查。 1.3 对服用NSAID的612例患者与未服用NSAID的601例患者对比分析两组服药时间与溃疡发生率及差异。 2 结果 2.1 1213例老年患者内镜诊断结果 见表1。 2.2 98例老年患者服用NSAID时间与上消化道溃疡病变 见表2。 病理检查结果符合溃疡病变，NSAID组16.01%（98/612），非NSAID组3.66%（22/601），服用NSAID时间越长胃粘膜糜烂、溃疡发病率越高。 3 讨论 非甾体类抗炎药是一类具有解热、镇痛、抗炎、抗风湿作用的药物，传统NSAID包括临床应用的洛索洛芬、双氯芬酸、吡罗昔康、美洛昔康、依托利酸、舒