复方α―酮酸片治疗慢性肾病蛋白尿50例疗效分析.docVIP

复方α―酮酸片治疗慢性肾病蛋白尿50例疗效分析 　　[摘要] 目的 探讨复方α-酮酸片治疗慢性肾病蛋白尿的临床疗效。 方法 选择94例慢性肾病蛋白尿患者，按随机数字表法分为对照组（44例）和治疗组（50例）。对照组口服氢氯噻嗪、依那普利，并给予低蛋白饮食，治疗组在对照组的基础上加服复方α-酮酸片（4～8片/次，3次/d）。两组疗程均为12周，观察治疗前后两组患者的24h尿蛋白定量、血清白蛋白、肌酐、尿素氮及临床疗效情况。 结果 治疗12周后，治疗组24h尿蛋白定量及尿素氮水平均明显低于对照组（P0.05），而血清白蛋白水平和治疗的总有效率均明显高于对照组，差异有统计学意义（P0.05）。 结论 复方α-酮酸片可以显著提高慢性肾病蛋白尿患者的血清白蛋白水平，有效控制蛋白尿。 　　[关键词] 复方α-酮酸片;慢性肾病;蛋白尿 　　[中图分类号] R692.5 [文献标识码] B [文章编号] 2095-0616（2015）02-49-03 　　The curative effect analysis of compound α-Ketoacid tablets on 50 cases chronic kidney disease patients with proteinuria 　　SUN Xuehui 　　Department of Nephrology，Tiexi District Center Hospital of Shenyang Province，Shenyang 110021，China 　　[Abstract] Objective To explore the clinical efficacy of compound α-Ketoacid tablets on chronic kidney disease（CKD）patients with proteinuria. Methods 94 Cases of CKD patients with proteinuria were randomly divided into control group（44 cases）and treatment group（50 cases）.The control group were treated with hydrochlorothiazide tablets and enalapril and given a low-protein diet，while the treatment group were given compound α-Ketoacid tablets（4 to 8 tablets a time，tid）on the basis of the control group.Both group were treated for 12 weeks.And compare the 24h urine protein quantitation，plasma protein，creatinine，urea nitrogen，and the clinical efficacy of the two groups. Results After 12 weeks，the 24h urine protein quantitation and urea nitrogen level of the treatment group were all significantly lower than the control group（P0.05），while the plasma protein level and the total effective rate of the treatment group were all significantly higher than the control group（P0.05）. Conclusion The therapy of compound α-Ketoacid tablets can significantly improve plasma protein level and control the level of proteinuria for CKD patients with proteinuria. 　　[Key words] Compound α-Ketoacid;Chronic kidney disease;Proteinuria 　　慢性肾病（chronic kidney disease，CKD）指肾损伤（包括肾脏病理学检查异常和有肾移植病史）或肾小球滤过率低于60mL/（min?1.73m2）持续至少3个月[1-2]。其临床表