alternate methodfor determinationofp ka- r i t- people（methodfor alternate determinationofp kat - r i t - people）.docVIP

Alternate Method for Determination of pKa The Method of Albert and Serjeant Background: In the pharmaceutical industry pKa is an important factor is drug design and development. It is important in drug ligand interactions (how the drug works) and is also important in the partitioning behavior of the potential drug candidate (how the drug gets into the body). As you are now aware there are several way to go about this determination. In this lab you will be introduced to the current method employed by most companies to make this experimental determination. Selection of the pKa at 1/2 Ve