前列地尔治疗肝硬化腹水的临床观察-哈药集团生物工程有限公司.docVIP

前列地尔注射液治疗肝硬化腹水伴黄疸的临床疗效观察 施海东 （张家港市第一人民医院感染科，江苏 张家港 215600） 摘要：目的 通过观察前列地尔注射液对肝硬化腹水伴黄疸患者症状及血生化指标的改善情况，评价前列地尔改善肝硬化患者脏器功能的临床疗效。方法 选择肝硬化腹水伴黄疸患者70例，随机分成治疗组35例和对照组35例，对照组予谷胱甘肽保肝，呋塞米、螺内酯利尿，人血白蛋白支持治疗；治疗组在给予相同的保肝、支持、利尿等处理的基础上加用前列地尔10μg加入5％葡萄糖100ml中静滴，每日2次，治疗4周观察治疗前后总胆红素（TBil）、丙氨酸转氨酶（ALT）、凝血酶原活动度（PTA）、尿素氮（BUR）、肌酐（Cr）变化及黄疸、腹水消退情况，并随访3个月观察长期疗效。结果 治疗组和对照组ALT、TBil、BUR、Cr较治疗前有明显降低，但是治疗组降低的幅度优于对照组（P0.01）；治疗组PTA较治疗前显著升高，治疗组腹水及黄疸消退情况明显优于对照组（P0.01）；出院后随访2个月，ALT、BUR、Cr仍维持在出院时水平。结论 前列地尔对肝硬化腹水患者脏器功能有明显改善作用，并且长期疗效显著。 关键词：肝硬化；腹水；黄疸；前列地尔 中图分类号： 文献标识码：A 文章编号： Clinical observation of alprostadil injection in the treatment of liver cirrhosis with jaundice SHI Hai-dong. (Department of Infectious Diseases,the 1st People＇s Hospital of Zhangjiagang City，Zhangjiagang, Jiangsu 215600，China) Abstract: Objective To observe the improvement of symptoms,blood biochemical indexes and organ function as a result of alprostadil injection in patients with liver cirrhosis combined with jaundice. Methods 70 patients with liver cirrhosis associated with jaundice were selected and randomly divided into treatment group(n=35) and control group(n=35). The patients in control group were treated with glutathione, furosemide, spironolactone diuretic, human serum albumin for support treatment whereas the patients in treatment group were given the same treatment as the control group plus alprostadil 10ug in 100ml 5% glucose intravenous infusion, 2 times a day for 4 weeks. The changes of TBIL,PTA,ALT,BUN,CR and jaundice,ascites were observed.The changes were evaluated after follow-up time of three months after treatment. Results The TBIL,ALT,BUR,CR were significantly decreased after treatment, while the PTA was increased in both groups（P0.01）.But the changes were more significant in the treatment group. The regression of ascites and jaundice in the treatment group were more significant than that in the control group (P 0.01). At follow-up three months after discharge, ALT,TBIL,BUR,CR remained at th