碳水化合物的主题[精选].ppt

FUTURE RESEARCH * FUTURE RESEARCH * FUTURE RESEARCH * FUTURE RESEARCH * FUTURE RESEARCH * FUTURE RESEARCH * FUTURE RESEARCH * FUTURE RESEARCH * FUTURE RESEARCH * The Japan EPA Lipid Intervention Study (JELIS) evaluated the effects of eicosapentaenoic acid (EPA; n-3 polyunsaturated fatty acid) on coronary artery disease (CAD) among subjects with hypercholesterolemia but no evidence of coronary artery disease (CAD; n=14,981). Subjects with abnormal TG and HDL-C levels (TG ≥150 mg/dL; HDL-C 40 mg/dL) had an increased CAD hazard ratio (HR, 1.71; 95% confidence interval [CI], 1.11–2.64; P=0.014) vs subjects with normal levels. As shown in the slide, EPA treatment suppressed the risk for CAD among individuals with abnormal TG and HDL-C levels by 53% (HR, 0.47; 95% CI, 0.23–0.98; P=0.043). The authors concluded that given the reduction in CAD event incidence among subjects with elevated TG and low HDL-C, EPA may beneficial for subjects with this dyslipidemic pattern. Saito Y, Yokoyama M, Origasa H, et al. Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS). Atherosclerosis. 2008;200(1):135-140. Diet Interventions after MIDART DART 1989 Diet and Reinfarction Trial 2033 men post MI; Duration: 2 years Randomized 1. Eat fatty fish 2-3 x per week 2. Increase cereal fiber 3. Decrease total fat, increase polyunsaturated fat No change in fat advice or fiber advice groups 29% reduction in all-cause mortality in fish group Diet Interventions Post-MICardioprotective Diet Trial 505 subjects with suspected AMI. Randomized, single-blind; both groups on a low fat diet. The intervention group (Group A) was advised to eat more fruit, vegetables, nuts, and grain products Cholesterol fell by 0.74 mmol/L in group A versus 0.32 mmol/L in group B Weight fell by 7.1 versus 3.0 kg, (CI 95%, 0.52–7.68). Cardiac events lower in group A than