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靶向COX 作者：谯敏，向廷秀，王丕龙，黄爱龙 【关键词】 RNA干扰；环氧化酶 【Abstract】AIM: To investigate the inhibitory effect of siRNA targeting COX2 on the growth of gastric carcinoma cells of well, moderate or poor differentiation (MKN28, SGC7901, BGC823) and related mechanism. METHODS: siRNA targeting COX2 gene was designed, siRNACOX2 vector was constructed and transfected into gastric carcinoma cells to induce RNA interference. The changes of COX2 were detected with RTPCR and Western blotting.Cell viability was detected by MTT. Cell apoptosis was judged by TUNEL and electro